Does OLAW expect the IACUC to notify NIH when there is a change in an animal activity supported by PHS funds?
The terms “significant change” and “change in scope” have different meanings. According to NIH Grants Policy Statement (GPS), change in scope refers to a change in the direction, type of research or training from the aims, objectives, or purposes of the approved project. A change in an animal activity can be both a significant change requiring IACUC review and a change in scope requiring notification to the NIH funding component. However, a significant change is not necessarily a change in scope. For a review of significant changes that require IACUC approval see OLAW FAQ D9 of Protocol Review. The investigator is responsible for submitting a proposed significant change in an animal activity to the IACUC for review and approval prior to implementing the change. As described in the PHS Policy IV.B.7, the IACUC is responsible for reviewing the significant change and approving, requiring modifications (to secure approval), or disapproving the proposed change. The IACUC is not required to
