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Does ribavirin impact on the hospital course of children with respiratory syncytial virus (RSV) infection?

April 26, 2017children course hospital impact infection respiratory ribavirin RSV syncytial virus

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Does ribavirin impact on the hospital course of children with respiratory syncytial virus (RSV) infection?

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Law BJ; Wang EE; MacDonald N; McDonald J; Dobson S; Boucher F; Langley J; Robinson J; Mitchell I; Stephens D Winnipeg Children’s Hospital and University of Manitoba, Winnipeg, Manitoba, Canada. OBJECTIVES: To determine the relationship between receipt of aerosolized ribavirin and the hospital course of high-risk infants and children with respiratory syncytial virus (RSV) lower respiratory infection (LRI). METHODS: The 1993-1994 Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) RSV database consists of prospectively enrolled children with acute RSV LRI, admitted to nine Canadian pediatric tertiary care centers. After excluding cases with compromised immunity and/or nosocomial infection, subsets with any congenital heart disease (CHD), chronic lung disease (CLD), age .35 (EARLY HYPOXIA) were studied in two ways. First, each risk group subset was analyzed separately to assess the association between ribavirin receipt and measures of disease severity including