Does the SCSA test measure sperm chromatin abnormalities other than DNA fragmentation?
In addition to DFI, the SCSA test uniquely identifies a fraction of sperm with High DNA Stainability (HDS). HDS sperm are considered to be immature with unprocessed nuclear proteins and/or poorly condensed chromatin. Current data indicate that semen samples with a high percentage of HDS sperm (>15%) may have lower fertilization rates with conventional IVF (but not with ICSI).