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How are the induced pluripotent stem (iPS) cells produced?

April 26, 2017cells induced iPS pluripotent produced stem

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How are the induced pluripotent stem (iPS) cells produced?

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Currently, iPS cells are produced by inserting copies of four stem cell-associated genes; Oct 3/4, Sox 2, Klf4, and c-Myc (or Oct 3/4, Sox 2, Nanog, and LIN28) into specialized cells using viral vectors. Shinya Yamanaka produced the first iPS cells from mouse cells in 2006. This was followed in 2007 by the generation of iPS cells from human somatic cells by both the Yamanaka lab and the lab of James Thomson.