How can ph can modify the solubility of the drugs?
yes pH palys a vital role in solubilities of diferrent substances including drugs.stomach pH is usaully 2.while blood has nearly Neutral pH. Drug solubility is widely accepted as important in the candidate selection process. Solubility is essential if an orally administered drug is to be absorbed across the intestinal walls and enter the portal vein. Absorption is to be distinguished from bioavailability: the latter is less because first pass metabolism, protein binding, hydrolysis, and other degradative pathways reduce the systemic concentration from that observed in the portal vein. Most drugs are ionizable in water, having either proton acceptor groups (bases), proton donor groups (acids), or both (amphoterics). The principles will be illustrated with reference to bases, but the behavior of acids and amphoterics will be analogous. At high pH (at least 2 pH units above the pKa), bases will be fully un-ionized and their solubility will be a minimum, the intrinsic solubility. As the pH
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