How do CNS depressants work on the brain and body?
Benzodiazepines such as alprazolam (Xanax), diazepam (Valium), and triazolam (Halcion) depress the central nervous system (CNS). They are used by millions in the U.S. to treat anxiety and sleep disorders, including insomnia. These CNS depressants affect the brain neurotransmitter GABA (gamma-aminobutyric acid). GABA works by decreasing brain activity, which results in a drowsy or calming effect. Barbiturates, including phenobarbital (Nembutal) and mephobarbital (Mebaral), are also CNS depressants. They are commonly prescribed to treat insomnia, tension, and anxiety. Taking CNS depressants for a few days to a few weeks may help you feel calm and sleepy. After a while, however, you will need larger doses to get the same calm and sleepy feeling. In addition, using CNS depressants with alcohol can slow down your heart and respiration and lead to death. After taking CNS depressants for a long period of time, stopping suddenly can have life-threatening consequences such as seizures.