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How do P. aeruginosa secreted products impact epithelial cell biology?

April 26, 2017aeruginosa Biology CELL epithelial impact products secreted

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How do P. aeruginosa secreted products impact epithelial cell biology?

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To approach this question, we have focused our efforts on a toxin we have discovered called Cif, for CFTR inhibitory factor. This secreted protein reduces the apical membrane expression of a number of ABC transporter-family proteins, including CFTR, the ion channel mutated in patients with CF.