How does histamine cause inflammation within the site of injury?
Vasodilation and the increase in permeability of blood vessels are cause by chemicals released by damaged cells in response to injury. One such substance is HISTAMINE, a chemical present in many cells of the body, especially in mast cells in connective tissue, circulating basophils,and blood platelets. Histamine is released in direct response to the injury of cells that contains it; it is also released in response to stimulation by certain components of the complement system. Phagocytic granules attracted to the site of injury can also produce chemicals that cause the release of histamine.
