How does the nerve gas sarin interfere with the so called neuromuscular junction?
Which neurotransmitter is involved? The neuromuscular junction is a neuronal controlled muscle cell membrane. The neuronal synapse stores acetylcholine neurotransmitters in small vesicle which are secreted to the synaptic cleft where they bind and activate acetylcholine receptors on the muscle cell membrane. To avoid overstimulation, acetylcholine is quickly removed by acetylcholine esterase hydrolysis. The nerve gas sarin inhibits the human type acetylcholine esterase thus over stimulating the muscles and causing cramps that leads to paralysis and suffocation. 14. List amino acids used as precursors for nucleic acid biosynthesis. Aspartate, Glutamine, Glycine 15. Describe the role of uric acid; orotic acid. – Orotic acid is the first pyrimidine intermediate in the synthesis of UTP and CTP. – Uric acid is the degradation product secreted from liver as the result of AMP, IMP and GMP degradation. 16. Describe the electron transport chain in the synthesis of deoxyribonucleotides (NDP to d
