How does the U01 differ from the R01 mechanism?
The major distinction between the U01 and R01 mechanisms regards collaboration between NIH and extramural researchers. Under the R01, all executive decisions are made by the PI without collaboration with NIH. Under the U01, the NIH has input on some decisions through input on the Steering Committee. An NIH Project Scientist will be assigned to each of the awarded U01 projects. There will be no more that 4 NIH Project Scientists participating as members of the GEDI Steering Committee; however, there will be only one NIH vote, reached by consensus. In addition, as with the R01 mechanism, a Program Director will be responsible for the normal scientific and programmatic stewardship of the U01 award. Additional information can be found in the RFA under section 2.A.2 NIH Responsibilities and section 2.A.3 Collaborative Responsibilities.
