How is IVIG administered?
As IVIG is a blood product, a needle must be inserted into the child’s vein and the solution of immunoglobulins is dripped in slowly over a few to several hours. The usual dose is 1-2 g/kg. How does IVIG work? IVIG probably has several mechanisms of action. It binds to autoantibodies and target cells and decreases levels of circulating immune complexes. It prevents the immune system from carrying out its attack. Are there risks associated with IVIG? During or after an IVIG infusion, there can be nausea, vomiting, flu-like symptoms, fever, and headache, which are resolved by decreasing the infusion rate. If these symptoms occur 1-2 days after the infusion, they generally resolve within 24-48 hours with Tylenol. More serious complications are rare. Where is IVIG given? The initial dose (if a child has never been on IVIG) should be administered in a hospital or outpatient clinic setting. Other treatments can be delivered at home by a registered nurse who is familiar with the protocol, pre
