How is LYRICA different from calcium channel blockers?
A5: LYRICA binds to the A2D subunit of voltage-gated calcium channels in central nervous system tissues. These channels allow the selective permeability of calcium ions across presynaptic plasma membranes in response to a presynaptic action potential. The A2D subunit is not a part of the calcium channel pore, but is an associated protein that modulates calcium channel activity. LYRICA does not completely inhibit calcium channel function or completely reduce neurotransmitter release, even at high concentrations. Calcium channel blockers bind to the A1 subunit of L-type calcium channels and directly block the ion-conducting pore. They work in peripheral vascular smooth muscle, preventing the movement of calcium. This relaxes arteries and reduces systemic blood pressure.
