How long does Extracel persist in vivo?
Residence time of Extracel in vivo depends on several factors, including the form in which it is implanted, the amount of crosslinker added, and the biological environment or system in which it is used. Extracel sponges have been shown to persist in a bone regeneration model for up to 8 weeks, while Extracel hydrogels last up to 4 weeks in a cartilage defect model. Aggressive environments with high mechanical stresses or blood flow will shorten the resorption period. Additionally, increasing cross-linking density can lengthen the degradation of the material.
