How much can I modify a chromatographic procedure and still be in compliance? Can column length, internal diameter, mobile phase composition be modified?
A. Chromatography contains a list of allowed adjustments to chromatographic systems. However, the user should verify the suitability of the method under the new conditions by assessing the relevant analytical performance characteristics potentially affected by the change (see section System Suitability under Chromatography ) back to top Q.
