How well does VENDYS correlate with conventional cardiovascular risk factors (Framingham Risk Score), subclinical atherosclerosis (coronary calcium score), and obstructive coronary artery disease (coronary angiography and myocardial perfusion)?
A11. Our studies have clearly demonstrated that lower VENDYS fingertip temperature rebound (TR) is associated with increased Framingham Risk Score (FRS) and higher coronary calcium score (CAC). More importantly, TR has been shown to significantly improve the predictive value of FRS in the detection of high-risk, subclinical atherosclerosis (CAC>100) in asymptomatic population. Similarly, we have also found that a combination of TR and FRS has shown a higher predictive power in the identification of obstructive coronary artery disease (diagnosed by coronary angiography and myocardial perfusion imaging) in vaguely symptomatic patients. These data suggest a potential clinical utility for VENDYS as a complementary, non-invasive, non-imaging, inexpensive test for cardiovascular risk assessment in asymptomatic and vaguely symptomatic populations. For more information, please see the Clinical Findings Section.
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