If a person starts with the 4-dose Twinrix schedule and then needs to switch to monovalent hepatitis B, which intervals should be used for subsequent doses?
If the person is switched from Twinrix to monovalent hepatitis B vaccine, revert to the monovalent minimum intervals for all doses. If the person has already received two doses of Twinrix using the 4-dose schedule at an interval of 7 days apart, the second hepatitis B dose given as Twinrix will not count using the monovalent schedule. The same principle applies when switching to monovalent hepatitis A vaccine.
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