Is dynamic modeling really predictive?
Yes it is. Statistical analyses show that the predictive power is highly significant (p<10-10). Simulations based on our human T-lymphocyte response model have identified a relevant and limited panel of drug targets. The benchmark analysis shows that one third of the selected targets are already experimentally validated (of which some are already targeted by drugs used in human clinics). The remaining ones will now be tested. This is to be compared to the high attrition rate of drug targeting by other existing methods (>90%).
