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Is it possible for the liver to develop a tolerance for giant level of acetaminophen?

April 26, 2017acetaminophen develop giant level liver possible tolerance

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Is it possible for the liver to develop a tolerance for giant level of acetaminophen?

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I know that an overdose of tylenol may cause acute liver disappointment, but is it possible for the liver to adjust?…e.g. if someone abuses Vicodin to the point that he/she is taking more than 4 grams a year, or 4 grams in a short spell of time (within 6 hours)…..