Is it safe to Take TZD drugs and Chiral Balance D-chiro-inositol?
Thiazolidinediones, such as Actos and Avandia, are prescribed to address the insulin resistance commonly associated with PCOS. Called TZD drugs or Glitazones, these drugs are often tried after Metformin. Avandia and Metformin are sometimes prescribed simultaneously as the combination drug Avandamet. The drugs bind to PPARs a modulating transcription of insulin-sensitive genes related to metabolism. In a sense, these drugs circumvent the steps of insulin signal transduction that are dysfunctional in insulin resistance. TZD drugs have side effects. Chiral Balance D-chiro-inositol (DCI) addresses insulin resistance in a different way. There is evidence that women with PCOS are deficient in DCI. Chiral Balance DCI supplement ensures the body has sufficient DCI to respond to insulin normally. Chiral Balance DCI addresses the suggested cause of insulin resistance whereas TZD drugs address the symptoms. Chiral Balance DCI has no known side effects.
