…I am supposed to start using Progesterone in oil injections during my upcoming IVF cycle. I believe this is a ‘natural’ form of progesterone, but wanted to be sure. I have read that there may be a slight increase in birth defects associated with the ‘synthetic’ forms of progesterone (Progestins). I became a bit concerned upon reading the insert that accompanied the drug since it warns of potential risks associated with taking progesterone during the first trimester of pregnancy, including birth defects (genital deformities). I am assuming the FDA requires that the warnings be put in regardless of the type of progesterone, natural or synthetic, but would like some reassurance. Can you please help me to understand why we need to continue the use of the progesterone after implantation of a pregnancy? Are there other options such as Crinone (progesterone vaginal gel) which is approved by the FDA for use in assisted reproductive technology. You do not need to worry about using natural pr