Important Notice: Our web hosting provider recently started charging us for additional visits, which was unexpected. In response, we're seeking donations. Depending on the situation, we may explore different monetization options for our Community and Expert Contributors. It's crucial to provide more returns for their expertise and offer more Expert Validated Answers or AI Validated Answers. Learn more about our hosting issue here.

Minor Allele Frequency (MAF) found in the population diversity section of the refSNP report is very high in SNPs from different sets of samples from the same ethnicity. Why?

April 26, 2017different Diversity high MAF minor allele frequency population refsnp report section SNPs

0

10 Posted

Minor Allele Frequency (MAF) found in the population diversity section of the refSNP report is very high in SNPs from different sets of samples from the same ethnicity. Why?

1 Answer

0

10 Posted

rs6523677 is annotated as “A” in the reference sequences, but the genotyping (HapMap) of 300 individuals shows a “C” for all alleles. It’s very unlikely that genotyping of any 300 individuals will show a “C” allele 300 times.