My compounds show activity in models for more than one disorder. Can I include multiple indications in a single application?
Multiple disorders are discouraged. This is because the target patient population and intended use guides the design of the drug and the pre-clinical studies, such as toxicology and formulation. For example, a drug for stroke will have different properties than a drug for Alzheimers, even though the molecular target of drug action may be shared. You may discuss the future potential for your drug to be used in other indications, but you should select a specific disorder for initial development in the Network. In your application, you should include a completed table of Key Drug Characteristics specific to your target disorder. A template for this table can be found at: http://www.neuroscienceblueprint.nih.gov/bpdrugs/apply.htm.
