page 399 – why are glucocorticoids necessary to facilitate catacholamine synthesis?
Dr. Caplan: It turns out that glucocorticoids do play a role in the development of the adrenal medulla and in catecholamine synthesis, both epinephrine and norepinephrine. According to Lange Endocrinology: Recently, patients with 21-hydroxylase and 11-hydroxylase deficiency have been shown to have adrenomedullary hypofunction secondary to low intra-adrenal concentrations of cortisol and developmental defects in formation of the adrenal medulla. Question: page 406 – Immunohistochemistry is in these notes but not your new notes, does that mean we ignore it… for that matter if there is something left out of the new notes, do we need to have it memorized? Dr. Caplan: Yes, with regard to immunohistochemistry, you can ignore that. I revised these notes to make your studying more bearable, so you can concentrate on those to study for the exam. Question: page 409 – under familial medullary thyroid cancer, why is it a variant of MEN -2A if there are no other manifestations of MEN…. seems li
