What application does yohimbine have?
Yohimbine has not been researched as thoroughly in the area of fat loss as many other weight loss aids, especially where clinical trials are concerned, but the existing data is promising. A 3-week study in 1991 on 20 obese females on 1000 calorie diets found that 20 mg of yohimbine daily increased weight loss 3 lbs. over placebo (1). Multiple studies have found that yohimbine increases the amount of non-esterfied fatty acids (NEFAs), a product of lipolysis (the breaking down of fat), in the bloodstream in both lean and obese individuals (2, 3), and that this effect persists for at least 14 days, indicating that rapid tolerance does not develop (4). Yohimbine is also an appetite suppressant, and decreases energy intake in both lean and obese mice (5). How does yohimbine work? Yohimbine works by blocking alpha(2) adrenoreceptors. There are a number of feedback mechanisms that prevent the release of norepinephrine (NE), one of the body’s primary lipolytic hormones. When NE is released, su
