What are some of the advantages of using mass spectrometry techniques in clinical research?
The great advantage of mass spectrometry (MS) over other technologies for detecting and monitoring subtle changes in substances in the body is the ability to measure rapidly and inexpensively thousands of elements in a few drops of blood. Unlike 2DE, MS patterns generated from the thousands of proteins present in blood are difficult to analyze visually. However, the powerful computational ability of today’s computers makes it possible to analyze MS spectra rapidly and distinguish subtle differences in patterns between diseased and healthy people. Mass spectrometry-based proteomics analysis is extremely rapid. The entire process, from collecting blood to analyzing the MS spectrum, can occur in less than one minute. In addition, hundreds of samples can be analyzed sequentially, and extremely small amounts of protein can be detected.
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