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What are the cause of thrombocytopenia/low platelet count surrounded by dengue haemorrhagic restlessness?

April 26, 2017cause dengue haemorrhagic low PLATELET restlessness surrounded thrombocytopenia

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What are the cause of thrombocytopenia/low platelet count surrounded by dengue haemorrhagic restlessness?

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Thrombocytopenia in Dengue Haemorhagic Fever can be explained by the following mechanism: >>Dengue virus induces bone marrow suppression. >>Dengue virus can bind to human platelets in presence of virus specific antibody and immune mediate clearance of platelets. >>Spontaneous aggregation of platelets to vascular endothelial cell pre-infected by virus inducing aggregation, lysis and platelet destruction. >> Anti-platelet antibodies generated after dengue virus infection cause destruction of platelets.