What are the Functions of the Latent Proteins?
EBNA1: EBNA1 is a DNA binding protein that controls the replication of the virus within infected cells. EBAN1 is required for maintaining latency. (Baumforth et al., 1999) EBNA2: this protein results in B-Cell transformation by upregulating the genes that code for CD23, CD21, LMP1, and LMP2. (Baumforth et al., 1999) EBNA3A, EBNA3B, and EBNA3C: Little is known about these three proteins except that EBNA3A and EBNA3C are necessary for EBV transformation but EBNA3B is not. EBNA3C transactivates EBNA2 regulated genes but blocks the EBNA2 transactivation of LMP1 and LMP2. (Baumforth et al., 1999) EBNA-LP: EBAN-LP along with EBNA2 are the first EBV proteins to be expressed after infection of the B-Cell. They act together to activate cyclin D2 synthesis which allows the B-Cell to enter the G1 phase of the cell cycle. (Baumforth et al., 1999) LMP1: LMP1 is a protein similar to ion channels and G protein receptors. When LMP1 genes are expressed in latent cells a dramatic change in the phenotype
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