What are the symptoms of basal cell nevus syndrome?
In addition to the characteristic facial appearance and the predisposition for skin cancers, symptoms may include mental retardation, seizures, brain tumors, spontaneous bone fractures, and deafness. Pits are sometimes visible in the palms of the hand and soles of the feet. Abnormal tooth development can result from cysts in the upper and lower jaws. Other bone defects associated with the disease include scoliosis (curvature of the spine), kyphosis (severe rounding of the upper back), and rib abnormalities. Other symptoms of the disease in the eyes may include defects of the iris (See Anatomy of the Eye.), irregular pupils, cataracts, and blindness.