What biochemical factors might cause a problem with the synthesis of neurotransmitters and hormones in autism?
A deficiency of the intestinal enzyme DPP-IV (dipeptydal peptidase), which acts to catalyze the breakdown of proteins into amino acids, has been hypothesized as a contributing factor to autism. If proteins aren’t being degraded into the amino acid substrates necessary to form hormones and neurotransmitters, the resultant metabolic havoc would be severe indeed, compromising both brain and body function. The proliferation of yeast or toxins in the intestinal tract, yeast induced pancreatic atrophy, and/or problems with the synthesis or activation of the hormone secretin, could also cause a problem with protein catabolism resulting in a deficit of critical polypeptide biochemical catalysts. These gastrointestinal problems would also cause problems with the synthesis and degradation of the glucosenecessary to fuel the electro-chemical processes in the brain. A deficiency or uneven supply of glucose would result in a deficiency or uneven supply of the glucose energy derivative ATP (adenosin
