what can we learn about olfactory transduction from the fruitfly ?
The fruitfly, Drosophila melanogaster, has become one of the major model animals to study olfactory transduction. The fully decyphered genome of this species and the modern methods of engeneering relevant proteins directly from the genes are more than outweighing the disadvantages caused by the extreme smallness of the antennae. Another great advantage is the availability of mutants with certain defects in olfaction-guided behaviour. In Drosophila, meanwhile ~60 odorant-binding proteins are known and this is also the first insect species, in which olfactory receptor proteins have been characterized, interestingly their number is also ~60. On the antenna and maxillary palps we have described 17 morphological subtypes of sensilla with some 40 olfactory receptor neurons. Using antibodies against 5 different OBPs (OS-E, OS-F, LUSH. PBPRP2, PBPRP5) we have started to map the expression mosaic of these proteins and have found that: 1. OBP expression does correlate with morphological sensillu
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- what can we learn about olfactory transduction from the fruitfly ?
