What Cells Are Most Susceptible To Bioenergy Depletion?
Different individuals age at different rates, and the tissues within individuals age at different rates. The cells that are most susceptible to mitochondrial bioenergy depletion with advancing age are brain, skeletal muscle, and cardiac muscle cells aII of which have an exceptionally high need for oxygen and, as a result, are highly dependent upon mitochondrial oxidative phosphorylation as a source of adenosine triphosphate (ATP) for their energy needs. (Other tissues, which contain relatively few mitochondria, depend to a greater extent on glycolysis as a source of ATP for energy production).
