What developmental milestones are “normal” for CLS?
Developmental milestones will vary greatly by individual for several reasons. First of all, children naturally develop at different rates, and each individual’s genetics will play a role in how they develop. Additionally, Coffin-Lowry syndrome expresses much more mildly in females; developmental milestones in females can cover the range from severely retarded to near normal. Therefore, the information below is primarily aimed at males. Even among males, there is variability in how the syndrome is expressed. Development can also be affected by the presence or lack of hypotonia, hearing loss, and other secondary characteristics and symptoms of CLS. Prior to birth, growth is usually normal with normal birthweight. Males usually fall below the 3rd percentile in height. Note: The following information is anecdotal, based on data gathered from letters written by family members of individuals affected by Coffin-Lowry syndrome. Walking: Usually somewhere around 2-3 years. They may skip crawlin
