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• HISTAMINE BLOCKER (noun) The noun HISTAMINE BLOCKER has 1 sense: 1. a medicine used to treat the gastric effects of histamine in cases of peptic ulcers and gastritis and gastroesophageal reflux; works by blocking the effects of histamine on the receptor site known as H2 Familiarity information: HISTAMINE BLOCKER used as a noun is very rare.
