What is a zymogen & phosphorylation cascade, what is the significance of metabolic events affected by a cascad?
Your question is confusing …. here’s the break down A zymogen (or proenzyme) is an inactive enzyme precursor. A zymogen requires a biochemical change (such as a hydrolysis reaction revealing the active site, or changing the configuration to reveal the active site) for it to become an active enzyme. The biochemical change usually occurs in a lysosome where a specific part of the precursor enzyme is cleaved in order to activate it. The amino acid chain that is released upon activation is called the activation peptide. So in order to activate it there needs to be some sort of posttranslational modification done to the enzyme. There are about 30 or more posttranslational modifications that happens to different kinds of proteins. And one of the modifications is called phosphorylation. What this does is to add a phosphate group to the zymogen enzyme and it activates zymogen by that addition. This is called “phosphorylation of zymogen”. Phosphorylation is usually done by a protein. Thus aft
