What is Integrated Screening?
Integrated screening involves a first trimester ultrasound of the nuchal translucency (NT) and maternal blood sample at 11 to 14 weeks combined with a blood test during second trimester, the Afp4, drawn between 16 and 22 weeks; Integrated screening evaluates the risk for Down syndrome, trisomy 18, and open neural tube defects. The results of the Integrated screening are only available in the second trimester, one week after the second blood test (Afp4) is analyzed. Integrated screening is the most sensitive screening test for the detection of Down syndrome, with a sensitivity of 92%. Integrated screening detects 80% of open neural tube defects.
This involves the measurement of the nuchal translucency by ultrasound and a blood draw in the first trimester for PAPP-A. You will not receive your test results at this time. Subsequently, you will have your blood drawn in the second trimester for AFP, HCG, Estriol and Inhibin. You will then receive your results. These results will assess your risk for Down syndrome, trisomy 18 and open neural tube defects. Approximately 92-95% of pregnancies affected with Down syndrome will have an increased risk or a screen positive result on an Integrated Screening test. What is Sequential Screening? This is similar to Integrated Screening, but results are shared with the patient after the first and second steps of the screening process. Approximately 91% of pregnancies affected with Down syndrome will present with an increased risk or a screen positive result on a Sequential screening test. What is a Neural Tube Defect? Very early in the pregnancy, the fetus forms a structure called the neural tub
Integrated screening is a test for Down syndrome. Compared with other screening tests, integrated screening offers a high detection rate for Down syndrome and keeps the false-positive rate low. Question: When do I get the test results? Answer: A genetic counselor contacts you within one week after your second blood test. Question: What happens if I screen positive? Answer: A genetic counselor helps you schedule a follow-up, if needed.
