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What is solid-phase sequencing?

April 26, 2017sequencing solid-phase

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What is solid-phase sequencing?

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The use of a solid support for attachment of DNA has been used in order to physically separate the single strands of DNA without the use of gel purification. The opposite strands of DNA can then be independently sequenced for verification. More recently, the use of paramagnetic particles has been developed for use as the attachment medium. DNA strands can then be separated by magnetic force and used in conjunction with sequencing techniques. For more information see Fry1992.