What is the association between PXE and testicular microlithiasis?
1. Testicular microlithiasis is a condition in which very small mineral deposits (microliths) are distributed randomly in the testicles. The condition is asymptomatic (causes no symptoms), so it is typically discovered during testing for other testicular anomalies. According to the study, testicular microlithiasis does not appear to be the risk factor for testicular cancer for males with PXE that it may be for the males in the general population. There is no known association between PXE and testicular cancer. Further, it may be that testicular microlithiasis merely represents another manifestation of PXE. The authors recommend that males with PXE with confirmed testicular microlithiasis remain under long-term observation by ultrasonography and physical examination. This finding has been confirmed by other authors.