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What is the basis of differing actions of antineoplastic agents on different tissue/neoplasms?

April 26, 2017Actions agents antineoplastic basis different differing neoplasms tissue

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What is the basis of differing actions of antineoplastic agents on different tissue/neoplasms?

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What is the basis for differing tissue- and neoplasm-specificites of antieoplastic chemotherapeutic agents? This doubt arose because considering what the pharmacokinetics of these drugs are it remains to be answered as to why a certain agent would act only in a particular tissue or neoplasm when the mechanisms they employ are so similar, e.g., various alkylating agents in spite having same action act of different tumors with differing degrees of effectiveness. Hope someone answers the question specifically. Useful links to free-text articles would also be highly appreciated. Bye. TC.