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What is the difference between EGFR (Her-1) and Her-2/neu?

April 26, 2017difference egfr her-2 NEU

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What is the difference between EGFR (Her-1) and Her-2/neu?

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EGFR and Her-2/neu are both members of the same family of cell membrane receptors. They are both measured in tumor tissue and evaluated for over-expression or amplification. When either EGFR or Her-2/neu is significantly increased in a cancer, it indicates a more aggressive tumor and a poorer patient prognosis. The primary differences between EGFR and Her-2/neu are that they are ordered to help evaluate different types of cancer and that the drugs that have been developed to target them are specific for that particular receptor, EGFR or Her-2/neu. Her-2/neu is used for diagnosis and prognosis of breast cancer.