What is the link to hormone balance and depression with PMS?
PMS-D (D = depression) is the least common type and is relatively rare in its pure form. Its key symptom is depression, which is usually associated with low levels of neurotransmitters in the central nervous system. In PMS-D patients, this is probably due to increased breakdown of the neurotransmitters as a result of decreased levels of estrogen (in contrast to PMS-A, which shows the opposite results). The decreased ovarian estrogen output has been attributed to a stress-induced increase in adrenal androgen and/or progesterone secretion.
