What is the medical definition of MDR-TB and XDR-TB?
MDR-TB, or multidrug-resistant TB, is a specific form of drug-resistant TB. It occurs when the TB bacteria are resistant to at least isoniazid and rifampicin, the two most powerful anti-TB drugs. XDR-TB is TB that is resistant to any fluoroquinolone, and at least one of three injectable second-line drugs (capreomycin, kanamycin, and amikacin), in addition to MDR-TB. This definition of XDR-TB was agreed by the WHO Global Task Force on XDR-TB in October 2006.