What is the receptor population for the Adult Lead Methodology?
In the commercial/industrial setting, the most sensitive receptor is the fetus of a worker who develops a body burden as a result of non-residential exposure to lead. This body burden is available to transfer to the fetus for several years after exposure ends (Gulson et al., 1998; Gulson et al., 1999). Based on the available scientific data, a fetus is more sensitive to the adverse effects of lead than an adult (National Academy of Sciences, 1993). We assume that cleanup goals (preliminary remediation goals or PRGs) that are protective of a fetus will also afford protection for male or female adult workers. The model equations were developed to calculate cleanup goals such that there would be no more than a five per cent probability that fetuses exposed to lead would exceed a blood lead (PbB) of 10 micrograms lead per deciliter of blood (g/dL). This same approach also appears to be protective for lead’s effect on blood pressure in adult males (see Adult Lead Methodology Review Report a
In the commercial/industrial setting, the most sensitive receptor is the fetus of a worker who develops a body burden as a result of non-residential exposure to lead. This body burden is available to transfer to the fetus for several years after exposure ends (Gulson et al., 1998; Gulson et al., 1999). Based on the available scientific data, a fetus is more sensitive to the adverse effects of lead than an adult (National Academy of Sciences, 1993). We assume that cleanup goals (preliminary remediation goals or PRGs) that are protective of a fetus will also afford protection for male or female adult workers. The model equations were developed to calculate cleanup goals such that there would be no more than a five per cent probability that fetuses exposed to lead would exceed a blood lead (PbB) of 10 micrograms lead per deciliter of blood (g/dL). This same approach also appears to be protective for leads effect on blood pressure in adult males (see Adult Lead Methodology Review Report av
