What is the relationship between EPAs IRIS and the cancer guidelines?
An IRIS file may include descriptive and quantitative human health risk information on both noncancer and cancer effects. EPA’s cancer guidelines provide guidance to Agency risk assessors in developing the cancer risk assessment portion of the IRIS file. Since the mid-1980s, when IRIS was developed, the cancer summary files were guided first by the 1984 proposed cancer guidelines and then by the 1986 final Guidelines. While the 1986 guidelines have guided the development of the IRIS cancer risk information for many years, cancer risk assessments have been informed by other considerations such as evolving science, the facts of the particular case, and scientific judgment. On November 29, 2001, EPA announced in the Federal Register that the July 1999 Draft Final Revised Guidelines would serve as interim guidance, and this is reflected in IRIS assessments developed since that time. The IRIS program will begin using the Guidelines in new or revised assessments.
Related Questions
- How were the cancer risk estimates affected by EPAs recently revised Guidelines for Carcinogen Risk Assessment (EPA/630/P-03/001F) and new Supplemental Guidance for Assessing Susceptibility from Early-Life Exposure to Carcinogens (EPA/630/R-03/003F)?
- What is the relationship between EPAs IRIS and the cancer guidelines?
- Why is EPA revising its 1986 final cancer guidelines?
