What is the therapeutic range of theophylline concentrations?
• The therapeutic range of theophylline concentrations is 10-20 µg/ml. • Drug concentrations less than 10 µg/ml are subtherapeutic, meaning that the patient’s asthma will not be adequately controlled. On the patient data cards, the clinical response notes will show “continued asthma.” • Drug concentrations 10-20 µ/g/ml are within the therapeutic range. On the patient data cards, the clinical response notes will show “asthma controlled.” • A drug concentration greater than 20 µ/g/ml is supratherapeutic, meaning that the patient’s asthma is medically controlled but the patient experiences adverse effects. On the patient data cards, the clinical response notes will show “adverse effects.
