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DESCRIPTION Desloratadine, the major active metabolite of loratadine, currently is approved by the FDA for use in patients with seasonal and perennial allergic rhinitis and chronic idiopathic urticaria. This drug is significantly more effective than placebo in reducing seasonal and perennial allergic rhinitis and chronic idiopathic urticaria symptoms, including nasal congestion. It appears to have a prompt onset of action in patients with seasonal allergic rhinitis and chronic urticaria. Clarinex also is safe and effective in patients with concomitant seasonal allergic rhinitis and mild to moderate asthma. How the efficacy of desloratadine compares with that of loratadine and other second-generation agents remains to be determined. Desloratadine has a favorable safety profile. It is unlikely to cause somnolence and does not prolong the QTc interval or impair psychomotor performance or driving ability at recommended dosages. Clarinex appears to be less likely to interact with other drug