Why does naproxen sodium have sedative effects?
Naproxen sodium (Advil) doesn’t have that effect on me. I take it quite often, since I’m a runner. The active ingredient is ibuprofin (Motrin), which doesn’t make you sleepy, and the inert ingredients don’t make you sleepy. Not “you” personally, but sleepiness isn’t a side effect. Talk to your pharmacist. She will be able to tell you if there is a side reaction somewhere. I just thought about this: because it is a pain reliever and anti-inflammatory pill, it probably thins the blood slightly, which will reduce the oxygen to your brain. That will make you yawn and make you sleepy.