Why is it important to consider genome build for SNP selection?
With each version of the human genomic sequence released, there are changes in positions of genes, SNPs and other features. Taking this into account, the misspecification of positions for tagSNP selection in QuickSNP might lead to various discrepancies in the results. We therefore provide the option for users to indicate the genome build that they would like to employ. For example, if they are using genomic positions obtained from linkage studies, they should confirm which genome build was used in those studies and enter the correct information in QuickSNP. We accept genomic coordinates for NCBI genome build versions 34, 35 and 36, which correspond to UCSC genome assemblies July 2003(hg16), May 2004(hg17) and Mar 2006(hg18), respectively. For coordinates from even older genome assemblies, one can visit the resource http://genome.ucsc.edu/cgi-bin/hgLiftOver to perform the conversion manually and then enter the information in QuickSNP.
