Why is it recommended that we stock a minimum of 36 vials of Dantrium® IV or dantrolene sodium for injection, rather than 12 or 24?
To treat an MH episode, an initial dose of dantrolene at 2.5 mg/kg is recommended, with a suggested upper limit of 10 mg/kg. If a patient of average weight (approximately 70 kg) were to require dantrolene at the upper dosing limit, then at least 700 mg of dantrolene would be needed. In addition, a review of cases has shown that in a “worse case” scenario of a very large person (i.e., about 100-110 kg or 220–250 pounds) having an acute MH incident, as much as 8-10 mg/kg will be needed for treatment; higher doses may be required on rare occasions. Thirty-six (36) vials of dantrolene will allow for initial stabilization and treatment while more vials are being acquired to continue treatment, as needed.
Related Questions
- Must we stock 36 vials of Dantrium® IV or dantrolene sodium for injection if our OR is very close to a fully equipped hospital and the patient could be transported there quickly?
- Are there any advantages in sharing a supply of Dantrium® IV or dantrolene sodium for injection?
- Where should Dantrium® IV or dantrolene sodium for injection is kept?
