Why is the dose of Antizol increased after 36 hours?
Following the administration of multiple doses, fomepizole induces its own metabolism via the cytochrome P-450 mixed-function oxidase system. This causes a significant increase in fomepizole metabolism after 30-40 hours. Increasing the maintenance dose to 15 mg/kg every 12 hours will maintain therapeutic plasma concentrations of fomepizole after 36 hours.
