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Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?

April 26, 2017agents combination deacetylase fulfil histone Inhibitors potential require therapeutic

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Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?

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Histone deacetylase inhibitors have progressed rapidly from the laboratory to clinical testing. This review highlights the promising data for their combination with a wide range of established and novel anticancer agents and discusses the mechanisms that underpin these interactions.